Kiyokawa C, Fujito S, Mori O, Mochizuki M, Hashimoto T
Department of Dermatology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830, Japan.
Br J Dermatol. 1998 Oct;139(4):693-6. doi: 10.1046/j.1365-2133.1998.02470.x.
We describe a 68-year-old Japanese woman with erythematous and bullous skin lesions. Antibasement membrane zone antibodies of IgG class were detected in the serum, which reacted with the 230 kDa and 180 kDa bullous pemphigoid antigens on immunoblot analysis. The patient later developed corneal opacity in both eyes and a detachment of the epithelium in the centre of the cornea. However, no change was seen in the conjunctiva. These ocular lesions are different from those of cicatricial pemphigoid. The ocular lesions could be reproduced by injection of IgG from this patient into the stroma of the corneas of rabbits. Both the cutaneous and ocular lesions responded well to oral corticosteroid therapy. We diagnosed this patient as having bullous pemphigoid associated with a unique ocular lesion.
我们描述了一位68岁患有皮肤红斑和大疱性病变的日本女性。血清中检测到IgG类抗基底膜带抗体，免疫印迹分析显示其与230 kDa和180 kDa的大疱性类天疱疮抗原发生反应。该患者后来双眼出现角膜混浊以及角膜中央上皮脱离。然而，结膜未见变化。这些眼部病变与瘢痕性类天疱疮不同。将该患者的IgG注射到兔眼角膜基质中可再现眼部病变。皮肤和眼部病变对口服糖皮质激素治疗反应良好。我们诊断该患者患有与独特眼部病变相关的大疱性类天疱疮。
