Benedek G, Szekeres L, Zoltán O T, Obál F
Arzneimittelforschung. 1976;26(3):335-40.
The electroencephalographic effects of several doses of a brain edema inducing agent, triethyltinsulfate (TET), was studied by implanted epidural electrodes in cats. The effect of TET on the central nervous system was found to have two phases: 1. a six hours' acute toxic phase following TET administration, 2. An edematic phase developing on the 2nd to the 4th day. Similarly to our earlier observations brain edema induced by TET was found to be dose-dependent, as shown by EEG-s, and their analysis performed by computation.
通过在猫身上植入硬膜外电极,研究了几种剂量的脑水肿诱导剂三乙基硫酸锡(TET)的脑电图效应。发现TET对中枢神经系统的作用有两个阶段:1. 给药后六小时的急性毒性阶段,2. 第二至第四天出现的水肿阶段。与我们早期的观察结果相似,通过脑电图显示,TET诱导的脑水肿呈剂量依赖性,并通过计算进行分析。