Seedorf U
Institute for Arteriosclerosis Research, Westfalische Wilhelms-Universität Münster, Germany.
J Cell Biochem Suppl. 1998;30-31:158-67.
Gene targeting and the elucidation of mutations underlying inherited peroxisomal diseases have provided new insights in peroxisomal lipid metabolism in vivo. The work led to the identification of a novel peroxisomal beta-oxidation pathway and established clearly that genes, which are required for efficient peroxisomal oxidation of fatty acids, at the same time are key regulators of PPAR alpha function in vivo. The new mouse models may provide helpful tools in the search for unknown natural PPAR alpha agonists and in screening for in vivo PPAR alpha antagonists.
基因靶向技术以及对遗传性过氧化物酶体疾病潜在突变的阐明，为体内过氧化物酶体脂质代谢提供了新的见解。这项工作促成了一种新型过氧化物酶体β-氧化途径的发现，并明确证实，脂肪酸在过氧化物酶体中高效氧化所需的基因，同时也是体内PPARα功能的关键调节因子。这些新的小鼠模型可能会为寻找未知的天然PPARα激动剂以及筛选体内PPARα拮抗剂提供有用的工具。
