Kavanagh L W, Jaques L B
Arzneimittelforschung. 1976;26(3):389-92.
Instillation of a single dose of heparin into the lungs of the dog resulted in a steady prolonged hypocoagulability as measured by the Lee and White clotting time, partial thromboplastin and activated partial thromboplastin times. 15 mg of heparin/kg increased clotting time three to five times control values. The anticoagulant effect occurred within one hour and lasted 48 h or more, in contrast to the short effect of intravenous heparin. For doses of 8, 10, 12, 15 and 20 mg/kg, there was a corresponding increase in the area under the response curve. The very prolonged moderate anticoagulant state with intrapulmonary heparin did not show the wide fluctuations in coagulation test values which occur with intravenous heparin.
向狗的肺部注入单剂量肝素会导致凝血功能持续长时间降低，这可通过李氏和怀特凝血时间、部分凝血活酶时间以及活化部分凝血活酶时间来衡量。每千克体重15毫克肝素可使凝血时间增至对照值的三至五倍。与静脉注射肝素的短期效果相反，这种抗凝作用在一小时内出现，并持续48小时或更长时间。对于8、10、12、15和20毫克/千克的剂量，反应曲线下的面积相应增加。肺内注射肝素导致的极长时间的中度抗凝状态并未表现出静脉注射肝素时凝血测试值出现的大幅波动。
