Lewinsohn P M, Rohde P, Klein D N, Seeley J R
Oregon Research Institute, Eugene 97403-1983, USA.
J Am Acad Child Adolesc Psychiatry. 1999 Jan;38(1):56-63. doi: 10.1097/00004583-199901000-00020.
To examine the course of adolescent major depressive disorder (MDD) by comparing rates of mood and non-mood disorders between age 19 and 24 years in participants with a history of adolescent MDD versus participants with adolescent adjustment disorder with depressed mood, nonaffective disorder, and no disorder.
Participants from a large community sample who had been interviewed twice during adolescence completed a third interview assessing Axis I psychopathology and antisocial and borderline personality disorders after their 24th birthday: 261 participants with MDD, 73 with adjustment disorder, 133 with nonaffective disorder, and 272 with no disorder through age 18.
MDD in young adulthood was significantly more common in the adolescent MDD group than the nonaffective and no disorder groups (average annual rate of MDD = 9.0%, 5.6%, and 3.7%, respectively). Adolescents with MDD also had a high rate of nonaffective disorders in young adulthood (annual nonaffective disorder rate = 6.6%) but did not differ from adolescents with nonaffective disorder (7.2%). Prevalence rates of dysthymia and bipolar disorder were low (< 1%). Adolescents with adjustment disorder exhibited similar rates of MDD and nonaffective disorders in young adulthood as adolescents with MDD.
This study documents the significant continuity of MDD from adolescence to young adulthood. Public health implications of the findings are discussed.
通过比较有青少年重度抑郁症（MDD）病史的参与者与有青少年情绪低落型适应障碍、非情感障碍及无疾病的参与者在19岁至24岁之间的情绪障碍和非情绪障碍发生率，来研究青少年重度抑郁症的病程。
来自一个大型社区样本的参与者在青少年时期接受过两次访谈，在他们24岁生日后完成了第三次访谈，评估轴I精神病理学以及反社会和边缘型人格障碍：261名患有MDD的参与者、73名患有适应障碍的参与者、133名患有非情感障碍的参与者以及272名截至18岁无疾病的参与者。
青少年MDD组中，成年早期的MDD明显比非情感障碍组和无疾病组更常见（MDD的平均年发生率分别为9.0%、5.6%和3.7%）。患有MDD的青少年在成年早期非情感障碍的发生率也很高（非情感障碍年发生率 = 6.6%），但与患有非情感障碍的青少年（7.2%）没有差异。心境恶劣障碍和双相情感障碍的患病率较低（<1%）。患有适应障碍的青少年在成年早期出现MDD和非情感障碍的发生率与患有MDD的青少年相似。
本研究记录了MDD从青少年期到成年早期的显著连续性。讨论了该研究结果对公共卫生的影响。
