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大鼠乳汁中各种氨基糖苷类排泄的研究(作者译)

[Studies on the excretion of various aminoglycosides in rat milk (author's transl)].

作者信息

Scheer M

出版信息

Arzneimittelforschung. 1976;26(5):778-81.

PMID:989350
Abstract

10 mg/kg of strepto-, neo-, kanamycin, genta- and sisomicin were applied s.c. to rats in lactation. After 0.5, 1, 2, 4, 6, 8 and 24 h the animals were milked. The antibacterial concentrations in the milk were determined in comparison to the serum concentrations. Strepto-, neo- and kanamycin showed the highest concentrations in the serum, genta- and sisomicin the highest in the milk.

摘要

将链霉素、新霉素、卡那霉素、庆大霉素和西索米星以10毫克/千克的剂量皮下注射给哺乳期大鼠。在0.5、1、2、4、6、8和24小时后采集动物乳汁。测定乳汁中的抗菌浓度并与血清浓度进行比较。链霉素、新霉素和卡那霉素在血清中的浓度最高,庆大霉素和西索米星在乳汁中的浓度最高。

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