Stone P, Richards M, Hardy J
Department of Palliative Medicine, Royal Marsden Hospital, Sutton, Surrey, U.K.
Eur J Cancer. 1998 Oct;34(11):1670-6. doi: 10.1016/s0959-8049(98)00167-1.
This paper reviews current knowledge regarding cancer-related fatigue assessment, prevalence, mechanisms and management. Most quality of life questionnaires contain at least some items pertaining to fatigue and a number of more specific self-assessment tools have now also been developed. As a results, there is a growing body of literature which documents the extent and severity of fatigue in cancer populations. Unfortunately most of these studies are uncontrolled and do not, therefore, provide an accurate estimate of the prevalence or severity of cancer fatigue relative to that found in the general population. Data from controlled studies are limited and the results are conflicting. Cross-sectional studies suggest that fatigue is the result of a combination of physical and psychological causes. Although no one treatment is proven to alleviate cancer-related fatigue a number of strategies show therapeutic promise.
本文综述了目前有关癌症相关疲劳的评估、患病率、机制及管理的知识。大多数生活质量调查问卷至少包含一些与疲劳相关的项目，现在也已经开发出了一些更具体的自我评估工具。因此，有越来越多的文献记录了癌症患者群体中疲劳的程度和严重程度。不幸的是，这些研究大多没有对照，因此，相对于普通人群，它们并未准确估计出癌症疲劳的患病率或严重程度。对照研究的数据有限，结果也相互矛盾。横断面研究表明，疲劳是身体和心理因素共同作用的结果。虽然没有一种治疗方法被证明能缓解癌症相关疲劳，但一些策略显示出了治疗前景。
