[关于内源性阶段性精神病的改进预防：血清和红细胞中锂平行测定的若干方面（作者译）]
[On improved prophylaxis of endogenous-phasic psychoses: aspects of parallel determination of lithium in serum and erythrocytes (author's transl)].
作者信息
Demisch L, Bochnik H J
出版信息
Arzneimittelforschung. 1976;26(6):1149-51.
PMID:989403
Abstract
In 30% of the psychiatric patients investigated the lithium concentration in erythrocytes (RBC-lithium) is a more reliable indicator for the evaluation of the clinical response and the risk of toxicity. After lithium administration the lithium RBC levels increased within the first three weeks. Lithium RBC/plasma ratios are not different between unipolar, bipolar and schizo-affective psychoses. It was found that low lithium RBC/plasma ratios correspond with low monoamine oxidase (MAO) activity in platelets.
摘要
在接受调查的30%的精神科患者中，红细胞中的锂浓度（红细胞锂）是评估临床反应和毒性风险更可靠的指标。服用锂后，红细胞锂水平在前三周内升高。单相、双相和分裂情感性精神病患者的红细胞锂/血浆比率没有差异。研究发现，低红细胞锂/血浆比率与血小板中低单胺氧化酶（MAO）活性相关。
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