Bégué S
Etablissement de transfusion sanguine de Lyon, Miribel.
Transfus Clin Biol. 1998 Dec;5(6):411-4.
Leukodepletion is a significant factor of improvement of the quality and safety of blood cell components. By reducing residual leukocytes in the products to a rate below 1 million per unit, the risks of transmitting intralymphocyte viruses, provoking shivers and hypothermia reactions, and inducing anti-HLA alloimmunization are diminished, as well as bacterial contamination risks. The constant improvement of the performance and the use of leukodepletion filters allows this technique to be generalized to all red blood cell and platelet concentrates. Leukocytes retention devices on these filters are numerous and sensitive to the conditions for material use. Implementation of Leukodepletion at production stage must be carried out in a mastered framework of quality assurance.
白细胞去除是提高血细胞成分质量和安全性的一个重要因素。通过将产品中残留白细胞的比例降低到每单位低于100万个，可降低传播淋巴细胞内病毒、引发寒战和体温过低反应以及诱导抗人白细胞抗原同种免疫的风险，同时也降低了细菌污染风险。白细胞去除过滤器性能的不断提高及其应用使得该技术能够推广到所有红细胞和血小板浓缩物。这些过滤器上的白细胞截留装置种类繁多，且对材料使用条件敏感。在生产阶段实施白细胞去除必须在一个严格的质量保证框架内进行。
