Lydakis C, Chaudary A Y, Lip G Y
University Department of Medicine, City Hospital, Birmingham, UK.
Int J Clin Pract. 1998 Sep;52(6):418-21.
Nitrates are useful drugs in cardiovascular medicine. They have a presumed vasovagal effect, which is a rare but often under-recognised complication that is partly caused by central inhibition of the sympathetic nervous system. However, no consistent variable associated with the presumed vasovagal effects following nitrate administration can be identified, and there are only limited reports of the phenomenon in the literature. In fact, the true prevalence of such a complication is unknown, because no data from observational studies exist, although it would seem likely to be a rare event. A greater awareness and recognition of this unusual effect of nitrate use is necessary in view of the increasing use of nitrates. Fortunately, recovery is generally the rule with supportive management.
硝酸盐是心血管医学中常用的药物。它们具有一种推测的迷走血管效应，这是一种罕见但常常未被充分认识的并发症，部分原因是中枢对交感神经系统的抑制。然而，在硝酸盐给药后，无法确定与推测的迷走血管效应相关的一致变量，而且文献中关于该现象的报道也很有限。事实上，这种并发症的真实患病率尚不清楚，因为没有观察性研究的数据，尽管看起来这可能是一个罕见事件。鉴于硝酸盐的使用越来越多，有必要提高对硝酸盐这种不寻常效应的认识和识别。幸运的是，通过支持性治疗，一般都能康复。
