Oyre S, Paaske W P, Ringgaard S, Kozerke S, Erlandsen M, Boesiger P, Pedersen E M
Department of Cardiothoracic and Vascular Surgery T, Aarhus University Hospital, Skejby Sygehus, Denmark.
Eur J Vasc Endovasc Surg. 1998 Dec;16(6):517-24. doi: 10.1016/s1078-5884(98)80244-x.
To apply a new, automatic and non-invasive method for quantification of blood flow, dynamic cross-sectional vessel area, and wall shear stress (WSS) by in vivo magnetic resonance velocity mapping of normal subjects.
Prospective, open study.
Six young volunteers.
A three-dimensional paraboloid model enabling automatic determination of blood flow, vessel distensibility and WSS was applied to blood velocity determinations in the common carotid artery. Blood flow was also determined by a manual edge detection method.
Using the new method, the common carotid mean blood flow was 7.28 (5.61-9.63) (mean (range)) ml/s. By the manual-method blood flow was 7.21 (5.55-9.60) ml/s. Mean luminal vessel area was 26% larger in peak systole than in diastole. Mean/peak WSS was 0.82/2.28 N/m2. Manually and automatically determined flows correlated (r2 = 0.998, p < 0.0001). WSS and peak centre velocity were associated (r2 = 0.805, p < 0.0001).
Blood flow, luminal vessel area dilatation, and WSS can be determined by the automatic three-dimensional paraboloid method. The hypothesis of association between peak centre velocity and WSS was not contradicted by the results of the present study.
通过对正常受试者进行体内磁共振速度成像，应用一种新的、自动且无创的方法来定量血流、动态横截面血管面积和壁面切应力（WSS）。
前瞻性开放性研究。
6名年轻志愿者。
将一种能够自动测定血流、血管扩张性和WSS的三维抛物面模型应用于颈总动脉血流速度的测定。血流也通过手动边缘检测方法进行测定。
使用新方法，颈总动脉平均血流为7.28（5.61 - 9.63）（均值（范围））ml/s。通过手动方法测得的血流为7.21（5.55 - 9.60）ml/s。收缩期峰值时管腔血管面积比舒张期大26%。平均/峰值WSS为0.82/2.28 N/m²。手动和自动测定的血流具有相关性（r² = 0.998，p < 0.0001）。WSS与峰值中心速度相关（r² = 0.805，p < 0.0001）。
血流、管腔血管面积扩张和WSS可通过自动三维抛物面方法测定。本研究结果并未反驳峰值中心速度与WSS之间存在关联的假设。
