Suschke H J
Fortschr Med. 1976 Jun 3;94(16):977-80.
A multicentric open clinical trial was carried out by 8 practising specialists in dermatology or paediatrics in patients with bacterial skin diseases who were subjected to a systemic therapy with Syncillin (=Azidocillin). The Syncillin presentation for adults and schoolchildren was tablets of 750 mg each, and sachets of 125 mg or 250 mg for infants. The duration of treatment was 10 days. The parameters analyzed were bacteriological findings and the clinical course of disease. 71 (=74%) of the 96 patients included in this study were considered as cured, 21 (=22%) as improved and 4 patients (=4%) as unchanged. Bacterial identification was still positive in 10 cases after the termination of treatment. However, this did not preclude the assessments of ""cured'' (3 cases) or ""improved'' (7 cases). The tolerance of the preparation was considered as ""very good'' or ""good'' in 91 and as ""poor'' in 5 patients. The most common side effects were nausea and diarrhoea. Exanthema was observed in 2 cases. None of these side effects, however, made a discontinuation of medication necessary. The era of rational and well-directed chemotherapy enables good therapeutic approach also to bacterial skin diseases.
8位皮肤科或儿科执业专家对患有细菌性皮肤病且接受新青霉素（=叠氮西林）全身治疗的患者开展了一项多中心开放性临床试验。新青霉素供成人和学童使用的剂型为每片750毫克的片剂，供婴儿使用的剂型为125毫克或250毫克的药包。治疗持续时间为10天。分析的参数为细菌学检查结果和疾病的临床病程。本研究纳入的96例患者中，71例（74%）被视为治愈，21例（22%）病情好转，4例（4%）病情未变。治疗结束后，仍有10例细菌鉴定呈阳性。然而，这并不妨碍评定为“治愈”（3例）或“好转”（7例）。91例患者认为该制剂的耐受性“非常好”或“好”，5例患者认为“差”。最常见的副作用是恶心和腹泻。观察到2例皮疹。然而，这些副作用均未导致必须停药。合理且针对性强的化疗时代也为细菌性皮肤病带来了良好的治疗方法。
