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Peroxynitrite production and activation of poly (adenosine diphosphate-ribose) synthetase in spinal cord injury.

作者信息

Scott G S, Jakeman L B, Stokes B T, Szabó C

机构信息

Division of Critical Care Medicine, Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

出版信息

Ann Neurol. 1999 Jan;45(1):120-4.

PMID:9894885
Abstract

Peroxynitrite formation and the subsequent activation of the nuclear enzyme, poly (adenosine diphosphate [ADP]-ribose) synthetase (PARS), has been implicated in the pathogenesis of several neurodegenerative disorders. Here, we demonstrate that nitrotyrosine, an indicator of peroxynitrite generation, and poly (ADP) ribose, a marker of PARS activation, were selectively localized within tissues from spinal cord-injured rats. Our data implicate a role for peroxynitrite production and PARS activation in the development of spinal cord trauma.

摘要

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引用本文的文献

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