Giardini O, Murgia F, Martino F, Mannarino O, Corrado G, Maggioni G
Acta Haematol. 1978;60(2):100-7. doi: 10.1159/000207703.
Serum lipids, phospholipid fractions and the composition of serum lipid fatty acids were studied in 20 children presenting beta-thalassaemia major, 20 heterozygous children and 20 normal controls. Total serum phospholipids, their fractions and cholesterol were significantly lower in patients with thalassaemia major. These changes were referred to hepatic damage and to severe anaemia, respectively. Some serum lipid polyunsaturated fatty acids were significantly decreased in patients with thalassaemia major as compared to heterozygotes and normal controls. Since these alterations are a sign of lipid oxidation, the causes of this phenomenon are discussed.
对20名重型β地中海贫血患儿、20名杂合子患儿和20名正常对照者的血清脂质、磷脂组分及血清脂质脂肪酸组成进行了研究。重型地中海贫血患者的血清总磷脂、其组分及胆固醇显著降低。这些变化分别归因于肝损伤和严重贫血。与杂合子和正常对照者相比，重型地中海贫血患者的一些血清脂质多不饱和脂肪酸显著降低。由于这些改变是脂质氧化的标志，因此对这一现象的原因进行了讨论。
