Folland D S, Schaffner W, Ginn H E, Crofford O B, McMurray D R
JAMA. 1976 Oct 18;236(16):1853-6.
Fourteen workers in an isopropyl alcohol packaging plant became ill after accidental exposure to carbon tetrachloride. In four, renal failure or hepatitis developed. Isopropyl alcohol potentiation of carbon tetrachloride toxicity has been shown previously only in rats. Acetone, a product of isopropyl alcohol metabolism, is a major potentiator of carbon tetrachloride toxicity. Workers had elevated levels of acetone in samples of expired alveolar gas and thus were metabolically predisposed to carbon tetrachloride injury. Stricter limits for industrial carbon tetrachloride exposure should be established where concomitant isopropyl alcohol use occurs.
一家异丙醇包装厂的14名工人在意外接触四氯化碳后患病。其中4人出现肾衰竭或肝炎。异丙醇增强四氯化碳毒性此前仅在大鼠身上得到证实。丙酮是异丙醇代谢产物，是四氯化碳毒性的主要增强剂。工人们呼出的肺泡气样本中丙酮水平升高，因此在代谢上易受四氯化碳损伤。在同时使用异丙醇的地方，应制定更严格的工业四氯化碳接触限值。
