Ohnaka M, Iwamoto M, Sakamoto S, Niwa Y, Matoba H, Nakayasu K, Nakaya Y
Department of Nutrition, School of Medicine, Faculty of Integrated Arts, University of Tokushima, Japan.
Ann Nutr Metab. 1998;42(6):311-8. doi: 10.1159/000012750.
Diet-induced thermogenesis (DIT) is mainly an insulin-mediated response and the result of fat and glycogen synthesis. We investigated DIT at rest and after exercise to clarify the mechanism of exercise-induced changes in DIT in 6 healthy men (mean age 36 +/- 16 years). Subjects exercised for 1 h at 58% of maximal O2 consumption on a bicycle ergometer and then rested for 8 h sitting in a comfortable chair (exercise experiment). On a different day, subjects rested for 8 h without preceding exercising (non-exercise experiment). At 12.30 h, the subjects were given their second meal. DIT to individual meal did not differ significantly between the exercise and non-exercise days. Increased insulin sensitivity and increased free fatty acid oxidation by exercise may facilitate the conversion of glucose to glycogen in muscle. On the other hand, insulin secretion expressed as the ratio of plasma levels of insulin to glucose after the meal was significantly decreased in the exercise experiment (p < 0.05). Study of heart rate variability showed that sympathetic tone, a primary hormonal determinant of glucose metabolism during exercise, was increased and parasympathetic tone was decreased during the recovery period in the exercise experiment (p < 0.05). These findings suggest that changes in DIT are affected by many factors and may be related to the balance between these counteracting factors.
饮食诱导产热（DIT）主要是一种胰岛素介导的反应，是脂肪和糖原合成的结果。我们对6名健康男性（平均年龄36±16岁）在静息状态和运动后进行了DIT研究，以阐明运动引起DIT变化的机制。受试者在自行车测力计上以最大耗氧量的58%运动1小时，然后坐在舒适的椅子上休息8小时（运动实验）。在另一天，受试者不进行运动，休息8小时（非运动实验）。在12:30时，给受试者提供第二餐。运动日和非运动日之间，每餐的DIT没有显著差异。运动导致胰岛素敏感性增加和游离脂肪酸氧化增加，可能有助于肌肉中葡萄糖转化为糖原。另一方面，在运动实验中，餐后胰岛素分泌以血浆胰岛素与葡萄糖水平之比表示，显著降低（p<0.05）。心率变异性研究表明，在运动实验的恢复期间，作为运动期间葡萄糖代谢主要激素决定因素的交感神经张力增加，副交感神经张力降低（p<0.05）。这些发现表明，DIT的变化受多种因素影响，可能与这些相互抵消的因素之间的平衡有关。
