Arnold W, Weidauer H, Seelig H P
Arch Otorhinolaryngol. 1976 May 31;212(2):99-117. doi: 10.1007/BF00454270.
An allergic glomerunephritis was produced in rats by injection of an anti-basement-membrane-serum (IgG-fraction), taken from rabbits which were sensitized against a basement membrane fraction of rat-glomerula. Tissues from heart, liver, brain, lung and inner ear were compared with the well known alterations of the glomerula. Exclusively in stria vascularis and renal glomerula heavy changements of the basement membranes and endothelial cells could be shown by electronmicroscopic examination and by immunohistological methods.
通过注射取自对大鼠肾小球基底膜部分致敏的兔的抗基底膜血清(IgG 组分),在大鼠中诱发了过敏性肾小球肾炎。将心脏、肝脏、大脑、肺和内耳的组织与肾小球的已知变化进行了比较。通过电子显微镜检查和免疫组织学方法仅在血管纹和肾小球中可显示基底膜和内皮细胞的严重变化。