Okuda M
Arch Otorhinolaryngol. 1976 Jul 20;212(3):147-51. doi: 10.1007/BF00456691.
Immunoglobulins of different classes are known to play a role in humoral defense mechanism, and Immunoglobulin E, without any actual evidence, is also expected to perform the same function. From the point of the defensive role the present study was undertaken in nasal allergy by observing the way in which powdered carbon particles previously insufflated in the nasal cavities are rapidly removed by nasal provocation with a causative allergen extract. The ratio of disapperance time of the carbon powder after/before provocation decreased markedly in good proportion with the intensity of the provocative reaction. Both sneezing and nasal secretion provocated contributed to this removal of the powder. When the nasal cavity on one side only was provocated, the non-provoked side also showed a rapid disappearance of the powder. In conclusion, Immunoglobulin E serves as a gate keeper by removing allergens from the surface of the nasal mucous membrane and by inhibiting the penetration of allergens into the nasal mucous membrane.
已知不同类别的免疫球蛋白在体液防御机制中发挥作用，而免疫球蛋白E在没有任何实际证据的情况下，也被认为具有相同功能。从防御作用的角度出发，本研究针对鼻过敏展开，通过观察预先吹入鼻腔的碳粉颗粒在使用致敏变应原提取物进行鼻腔激发后被迅速清除的方式来进行。激发后碳粉消失时间与激发前的比值与激发反应强度呈显著比例下降。打喷嚏和激发引起的鼻分泌物都促成了碳粉的清除。当仅对一侧鼻腔进行激发时，未激发侧的碳粉也迅速消失。总之，免疫球蛋白E通过从鼻黏膜表面清除过敏原以及抑制过敏原穿透鼻黏膜，起到了门卫的作用。
