Okuda M
Arch Otorhinolaryngol. 1975 Oct 30;211(1):25-33. doi: 10.1007/BF00467287.
The response of the nasal mucous membrane to anti-human IgE serum was examined. The application of anti-IgE sera to the nasal mucous membrane induced a nasal allergy-like symptom as well as nasal eosinophilia. This symptom was observed in the majority of nasal allergy cases and in some vasomotor rhinitis cases, while not in non-allergic normal persons. The nasal eosinophilia, however, increased not only in allergic patients, but in non-allergic persons in whom no nasal symptoms were induced. Such a nasal reaction was not induced with anti-IgA sera or anti-IgG sera. The character of the reaction was presumed to be specific to anti-IgE and was predominantly a reversed type anaphylaxis in the nasal mucous membrane. The sensitivity of the nasal mucous membrane to anti-IgE decreased in the course of the hyposensitization with house dust. The cause of this phenomenon was obscure.
对鼻黏膜对抗人IgE血清的反应进行了研究。将抗IgE血清应用于鼻黏膜会引发类似鼻过敏的症状以及鼻嗜酸性粒细胞增多。这种症状在大多数鼻过敏病例以及一些血管运动性鼻炎病例中观察到，而在非过敏性正常人中未观察到。然而，鼻嗜酸性粒细胞增多不仅在过敏患者中出现，在未诱发鼻症状的非过敏者中也出现。用抗IgA血清或抗IgG血清不会诱发这种鼻反应。推测该反应的特征是抗IgE特有的，并且在鼻黏膜中主要是一种反向过敏反应。在用屋尘进行减敏治疗过程中，鼻黏膜对抗IgE的敏感性降低。这种现象的原因尚不清楚。
