Neuroleptic-induced akathisia and dystonia triggered by alcohol.

Subclinical extrapyramidal symptoms caused by phenothiazine or butyrophenone derivatives can become manifest during and shortly after the consumption of alcohol. Alcohol appears to lower the threshold of resistance to neurotoxic side effects of previously established neuroleptic drugs. Abstinence from alcohol should be routine advice during neuroleptic psychopharmacotherapy.