Balldin J, Alling C, Gottfries C G, Lindstedt G, Långström G
Psychopharmacology (Berl). 1985;86(1-2):142-6. doi: 10.1007/BF00431699.
Dopamine (DA) sensitivity, assessed through maximal growth hormone (GH) response to stimulation by apomorphine (APO) (0.18-0.24 mg iv) was studied in 16 chronic alcoholics newly admitted after a period of heavy alcohol intake. Repeated hormonal tests were thereafter performed during a 2-month period under strictly controlled conditions to avoid relapse into alcohol consumption. Eight healthy volunteers with alcohol consumption slightly less than that of the general population were used as controls. It was found that DA sensitivity in the early abstinence phase was higher than later in the 2-month recovery period but not significantly different from control values. The relatively higher DA sensitivity in the early abstinence phase might be responsible for a lower threshold for psychotic symptoms and neuroleptic-induced extrapyramidal side effects. The results of this study give further evidence of a prolonged recovery phase after heavy alcohol intake.
通过对16名在大量饮酒一段时间后新入院的慢性酒精中毒患者进行研究，评估了多巴胺（DA）敏感性，方法是检测其对阿扑吗啡（APO）（0.18 - 0.24毫克静脉注射）刺激的最大生长激素（GH）反应。此后，在严格控制的条件下，于2个月内进行重复的激素测试，以避免再次饮酒。选取8名饮酒量略低于一般人群的健康志愿者作为对照。研究发现，早期戒酒阶段的DA敏感性高于2个月恢复期的后期，但与对照值无显著差异。早期戒酒阶段相对较高的DA敏感性可能是导致精神病性症状阈值降低和抗精神病药物所致锥体外系副作用的原因。本研究结果进一步证明了大量饮酒后恢复期延长。
