Yue R H, Gertler M M, Starr T, Koutrouby R
Thromb Haemost. 1976 Jun 30;35(3):598-606.
The amount of antithrombin III in plasma was determined quantitatively in 218 males between 45-60 years of age. The mean antithrombin III value was found to be low in the group with low risk for ischemic heart disease, intermediate in the group with high risk for ischemic heart disease and highest in the group with acute myocardial infarction. Concomitant study of kaolin-activated partial thromboplastin time revealed a sharp decrease in its mean value in the group with acute myocardial infarction. The high correlation between antithrombin III and kaolin-activated partial thromboplastin time for the entire population suggests that the development of ischemic heart disease is a gradual process and that failure of the damping mechanism results as an acute event. These findings may be useful in the determination of the coagulation state of these patients.
对218名45至60岁男性的血浆抗凝血酶III含量进行了定量测定。结果发现，在缺血性心脏病低风险组中抗凝血酶III的平均水平较低，在缺血性心脏病高风险组中处于中等水平，而在急性心肌梗死组中最高。同时对高岭土激活的部分凝血活酶时间进行研究发现，急性心肌梗死组的平均水平急剧下降。整个人群中抗凝血酶III与高岭土激活的部分凝血活酶时间之间的高度相关性表明，缺血性心脏病的发展是一个渐进的过程，而阻尼机制的失效则作为一个急性事件出现。这些发现可能有助于确定这些患者的凝血状态。
