[免疫大鼠脾脏信使核糖核酸制剂对大鼠淋巴肉瘤抗体合成的影响]

[Effect of preparations of messenger RNA from the spleens of immunized rats on antibody synthesis in rat lymphosarcoma].

作者信息

Aksenova N N, Figel'man M L, Tsikarishvili T N, Fel' V Ia, Olenov Iu M

出版信息

Tsitologiia. 1976 Jul;18(7):871-5.

Abstract

Messenger RNA was isolated from spleen polysomes of rats immunized with sheep red cells, two methods being employed: a sorption of mRNA on on membrane filters, and poly(U)-cellulose affinity chromatography. The rat transplantable lymphosarcoma cells treated with this RNA started hemolysine synthesis which persisted throughout many cell generations in transplantation of the tumor. The probability is discussed of m-RNA not only functioning as a template for antibody synthesis but also deblocating appropriate genes in recipient cells.

摘要

从用绵羊红细胞免疫的大鼠脾脏多核糖体中分离信使核糖核酸（Messenger RNA），采用了两种方法：信使核糖核酸在膜滤器上的吸附以及聚（U）-纤维素亲和层析。用这种核糖核酸处理的大鼠可移植性淋巴肉瘤细胞开始合成溶血素，并且在肿瘤移植后的许多细胞代中持续存在。文中讨论了信使核糖核酸不仅作为抗体合成模板起作用，而且在受体细胞中使适当基因移位的可能性。

相似文献

1

[Effect of preparations of messenger RNA from the spleens of immunized rats on antibody synthesis in rat lymphosarcoma].[免疫大鼠脾脏信使核糖核酸制剂对大鼠淋巴肉瘤抗体合成的影响]

Tsitologiia. 1976 Jul;18(7):871-5.

2

The ability of rat transplantable lymphosarcoma cells to synthesize immunoglobulins.大鼠可移植性淋巴肉瘤细胞合成免疫球蛋白的能力。

Neoplasma. 1982;29(3):249-56.

3

Effect of exogenous immunogenic RNA on the antibody synthesis in rat transplantable lymphosarcoma cells.外源性免疫原性RNA对大鼠可移植性淋巴肉瘤细胞抗体合成的影响。

Neoplasma. 1983;30(4):395-402.

4

[Intercellular exchange of information during immunogenesis. I. Effect of RNA from the spleen of immunized rats on rat lymphosarcoma cells].[免疫发生过程中的细胞间信息交换。I. 免疫大鼠脾脏RNA对大鼠淋巴肉瘤细胞的作用]

Tsitologiia. 1969;11(3):389-92.

5

[Intercellular information transfer in the process of immunogenesis. VI. The induction of antiphage antibody synthesis in the cells of rat transplantable lymphosarcoma under the influence of splenic RNA from rats and mice immunized with phage T2].[免疫发生过程中的细胞间信息传递。VI. 用噬菌体T2免疫的大鼠和小鼠的脾脏RNA影响下大鼠可移植性淋巴肉瘤细胞中抗噬菌体抗体合成的诱导]

Tsitologiia. 1979 Apr;21(4):452-8.

6

[Antibody synthesis in cells of transplantable rat lymphosarcoma under the influence of low-molecular "immune" RNA].[低分子“免疫”RNA作用下可移植性大鼠淋巴肉瘤细胞中的抗体合成]

Vestn Akad Med Nauk SSSR. 1977(3):36-8.

7

[[Intercellular information flow in the process of immunogenesis. VII. The effect of low- and high-polymer immune nuclear RNA on antibody synthesis by the cells of rat transplantable]U].[免疫发生过程中的细胞间信息流。VII. 低聚和高聚免疫核RNA对大鼠可移植肿瘤细胞抗体合成的影响]

Tsitologiia. 1980 Oct;22(10):1214-9.

8

[New evidences of immune globulin synthesis by rat transplantable lymphosarcoma cells].

Tsitologiia. 1969 Jan;11(1):86-92.

9

[Intercellular information transfer in the process of immunogenesis. II. Antibody formation in the progeny of lymphosarcoma cells treated with spleen RNA from immunized rats and mice].[免疫发生过程中的细胞间信息传递。II. 用免疫大鼠和小鼠的脾脏RNA处理的淋巴肉瘤细胞后代中的抗体形成]

Tsitologiia. 1970 Oct;12(10):1315-21.

10

[Antibody synthesis in a primary culture of transplantable rat lymphosarcoma cells].[可移植大鼠淋巴肉瘤细胞原代培养中的抗体合成]

Tsitologiia. 1972 Aug;14(8):947-52.

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