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2,4-二硝基苯酚、碘乙酸、氟化钠及缺氧对豚鼠胎盘血浆息肉形成的影响(作者译)

[The effect of 2,4-dinitrophenol, monoiodine acetate, sodium fluoride and hypoxia on the formation of plasma polyps in the placenta of guinea pigs (author's transl)].

作者信息

Thorn W, Kaufmann P, Müldener B, Freese U

出版信息

Arch Gynakol. 1976 Oct 15;221(3):203-10. doi: 10.1007/BF00667715.

DOI:10.1007/BF00667715
PMID:990063
Abstract

Plasma polyps can be found at the end of a normal pregnancy. Following NaF and MJA-intoxication, there is an extreme increase of plasma polyps. This accelerated formation can be prevented by the injection of Na-pyruvate and often the number of polyps can be reduced below the norm. 2,4-Dinitrophenol intoxication and breathing of hypoxic gas mixture (2,5% O2, 5% CO2, 92,5% N2) do not lead to increased plasma polyp formation. This proves, that it is not hypoxia, not an energy deficit secondary to separation of oxydative phosphorylation and not cardiac insufficiency leading to secondary ischemia which are responsible for the extreme increase in the number of plasma polyps following the injection of MJA and NaF.

摘要

在正常妊娠末期可发现血浆息肉。在氟化物和甲基茉莉酮酸酯中毒后,血浆息肉数量会急剧增加。注射丙酮酸钠可防止这种加速形成,且息肉数量通常可减少至正常水平以下。2,4-二硝基苯酚中毒以及呼吸低氧气体混合物(2.5%氧气、5%二氧化碳、92.5%氮气)不会导致血浆息肉形成增加。这证明,注射甲基茉莉酮酸酯和氟化物后血浆息肉数量急剧增加的原因,既不是缺氧,也不是氧化磷酸化解偶联继发的能量不足,更不是导致继发性缺血的心脏功能不全。

相似文献

1
[The effect of 2,4-dinitrophenol, monoiodine acetate, sodium fluoride and hypoxia on the formation of plasma polyps in the placenta of guinea pigs (author's transl)].2,4-二硝基苯酚、碘乙酸、氟化钠及缺氧对豚鼠胎盘血浆息肉形成的影响(作者译)
Arch Gynakol. 1976 Oct 15;221(3):203-10. doi: 10.1007/BF00667715.
2
[Carbohydrate turn over, energy deficit and the formation of plasma polyps within the placenta after poisoning with monoiodineacetate and sodium fluoride (author's transl)].[一碘乙酸和氟化钠中毒后胎盘内碳水化合物周转、能量缺乏与血浆息肉的形成(作者译)]
Arch Gynakol. 1974 Mar 12;216(2):175-83. doi: 10.1007/BF00668391.
3
[The morphology of the guinea pig placenta after poisoning with monoiodineacetate and fluoride (author's transl)].[一碘乙酸和氟中毒后豚鼠胎盘的形态学(作者译)]
Arch Gynakol. 1974 Mar 12;216(2):185-203. doi: 10.1007/BF00668392.
4
Inhibition of phosphate and arsenate uptake in yeast by monoiodoacetate, fluoride, 2,4-dinitrophenol and acetate.单碘乙酸、氟化物、2,4-二硝基苯酚和乙酸对酵母中磷酸盐和砷酸盐摄取的抑制作用。
Biochim Biophys Acta. 1969 Apr 8;172(3):399-406. doi: 10.1016/0005-2728(69)90136-4.
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[In-vitro formation of plasma polyps in the human placenta and their isolation by means of "inverted centrifugation" (author's transl)].人胎盘血浆息肉的体外形成及其通过“反向离心”法的分离(作者译)
Res Exp Med (Berl). 1977 Sep 30;171(2):155-62. doi: 10.1007/BF01851362.
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Regulation of ATP sensitive potassium channel of isolated guinea pig ventricular myocytes by sarcolemmal monocarboxylate transport.肌膜单羧酸转运对豚鼠离体心室肌细胞ATP敏感性钾通道的调节
Cardiovasc Res. 1992 Nov;26(11):1077-86. doi: 10.1093/cvr/26.11.1077.
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Effect of anaerobiosis, dinitrophenol and fluoride on the active intestinal transport of galactose in snail.无氧、二硝基苯酚和氟化物对蜗牛肠道中半乳糖主动转运的影响。
Rev Esp Fisiol. 1975 Jun;31(2):125-30.
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Regulation of the pyruvate dehydrogenase activity in the isolated perfused heart of guinea-pigs.
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Effect of fluoride and dinitrophenol on acetate activation in kidney and liver homogenates.氟化物和二硝基苯酚对肾和肝匀浆中乙酸盐活化的影响。
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The effect of hypoxia and 2,4 dinitrophenol on human placental glycogen metabolism.缺氧和2,4-二硝基苯酚对人胎盘糖原代谢的影响。
Proc Soc Exp Biol Med. 1972 Jun;140(2):724-8. doi: 10.3181/00379727-140-36540.

本文引用的文献

1
Reversible inhibition of the coupling between phosphorylation and oxidation.磷酸化与氧化之间偶联的可逆抑制
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2
Studies on the cyclophorase system; the coupling of oxidation and phosphorylation.关于环化酶系统的研究;氧化与磷酸化的偶联。
J Biol Chem. 1949 Feb;177(2):655-78.
3
[The behavior of the energy metabolism in the warm-blooded heart in induced cardiac arrest].[诱导心脏骤停时温血心脏的能量代谢行为]
Pflugers Arch Gesamte Physiol Menschen Tiere. 1960;271:347-60.
4
[The effect of 2,6-bis(diethanolamino)-4, 8-dipiperidino-pyrimidino-(5,4-d)pyrimidine and of the glucuronide of this substance on blood pressure, metabolite content of the blood, liver and myocardium].[2,6-双(二乙醇氨基)-4,8-二哌啶基嘧啶并-(5,4-d)嘧啶及其葡糖醛酸苷对血压、血液、肝脏和心肌代谢物含量的影响]
Arzneimittelforschung. 1962 Jun;12:606-14.
5
[Metabolic processes in the brain in acute anoxia, acute ischemia and recuperation].[急性缺氧、急性缺血及恢复过程中大脑的代谢过程]
Pflugers Arch Gesamte Physiol Menschen Tiere. 1955;261(4):334-60. doi: 10.1007/BF00364124.
6
[Hydrogen ion concentration of cerebral cortex of rabbit in situ during peracute total ischemia, pure anoxia and during recuperation].[急性完全缺血、单纯缺氧及恢复过程中家兔原位大脑皮质的氢离子浓度]
Pflugers Arch Gesamte Physiol Menschen Tiere. 1954;258(6):501-10. doi: 10.1007/BF00363713.
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[The phosphocreatine content of the normal and ischemic brain].
Pflugers Arch Gesamte Physiol Menschen Tiere. 1965 Sep 15;285(4):331-4.
8
[The morphology of the guinea pig placenta after poisoning with monoiodineacetate and fluoride (author's transl)].[一碘乙酸和氟中毒后豚鼠胎盘的形态学(作者译)]
Arch Gynakol. 1974 Mar 12;216(2):185-203. doi: 10.1007/BF00668392.
9
[Carbohydrate turn over, energy deficit and the formation of plasma polyps within the placenta after poisoning with monoiodineacetate and sodium fluoride (author's transl)].[一碘乙酸和氟化钠中毒后胎盘内碳水化合物周转、能量缺乏与血浆息肉的形成(作者译)]
Arch Gynakol. 1974 Mar 12;216(2):175-83. doi: 10.1007/BF00668391.