Majteles M
Isr J Med Sci. 1976 Oct;12(10):1159-67.
A method is presented of calculating biological doses in combined external and intracavitary radiotherapy with long-lived radioisotopes. The method utilizes the well-known "nominal standard dose" concept combined with an original correction, based on a radiobiological model, to account for the nonhomogeneity of the external field therapy. Of practical interest are the points of maximal radiation dose sustained by the rectum and bladder in the treatment of carcinoma of the uterine cervix. Forty patients with malignant tumors of the uterine cervix who were treated at the Beilinson Hospital are described. A high degree of correlation was found between the biological dose and long-term regional complications. There appears to be a practical threshold dose, of about 4,000 rets, below which severe gastrointestinal and genitourinary complications are rare. A strategy of optimal treatment leading to limited complications is presented.
本文介绍了一种在使用长寿命放射性同位素进行体外和腔内联合放射治疗时计算生物剂量的方法。该方法利用了著名的“标称标准剂量”概念，并结合基于放射生物学模型的原始校正，以考虑外照射治疗的非均匀性。在子宫颈癌治疗中，直肠和膀胱所承受的最大辐射剂量点具有实际意义。本文描述了在贝林森医院接受治疗的40例子宫颈恶性肿瘤患者。发现生物剂量与长期局部并发症之间存在高度相关性。似乎存在一个约4000雷姆的实际阈值剂量，低于该剂量，严重的胃肠道和泌尿生殖系统并发症很少见。本文还提出了一种导致并发症有限的最佳治疗策略。
