Diaz F A, Bianco J A, Bello A, Beer N, Velarde H, Izquierdo J P, Jaen R
Br J Anaesth. 1976 Oct;48(10):941-6. doi: 10.1093/bja/48.10.941.
Left ventricular contractility was assessed before and during the peak effect of ketamine in eight canine right heart bypass preparations. Myocardial contractility was defined in terms of maximum left ventricular dp/dt, the ejection fraction, and left ventricular end-diastolic and left atrial pressures at constant heart rate and cardiac inflow. Ketamine produced significant decreases in contractility and there were some indications of a dose-response pattern. The action of ketamine was dependent partly on changes in arterial pressure, as the drug caused a mild but sustained vasodilatation which was not dose-dependent. These data offer further evidence of a small and transient negative inotropic effect of ketamine.
在八个犬类右心旁路制备模型中，于氯胺酮达到峰值效应之前及期间评估左心室收缩力。心肌收缩力通过最大左心室dp/dt、射血分数以及在恒定心率和心脏流入量时的左心室舒张末期压力和左心房压力来定义。氯胺酮使收缩力显著降低，并且有一些剂量反应模式的迹象。氯胺酮的作用部分取决于动脉压的变化，因为该药物引起轻度但持续的血管舒张，且这种舒张不依赖于剂量。这些数据进一步证明了氯胺酮具有轻微且短暂的负性肌力作用。
