Weintraub A H, Khan I, Karptkin S
Br J Haematol. 1976 Nov;34(3):421-6. doi: 10.1111/j.1365-2141.1976.tb03588.x.
Rabbits subjected to chronic blood loss with iron supplementation raised their platelet count and megathrombocyte number 1.7 x and 2.1 x above baseline, respectively. In similarly treated splenectomized animals, no significant response was obtained. When chronic blood loss plasma was injected into recipient animals there was a rise in platelet count and megathrombocyte number of 1.8 x and 3.4 x respectively compared to animals injected with control plasma. In similarly treated splenectomized animals no such rise was obtained; neither was there a rise in platelet count or megathrombocyte number in intact recipient animals when chronic blood loss plasma was obtained from splenectomized animals. It is concluded that the thrombocytosis of chronic blood loss requires the presence of an intact spleen. The data suggest tha presence of a release factor which requires the spleen for its elaboration as well as expression.
接受慢性失血并补充铁剂的兔子，其血小板计数和巨型血小板数量分别比基线水平升高了1.7倍和2.1倍。在经过类似处理的脾切除动物中，未获得显著反应。当将慢性失血血浆注入受体动物时，与注射对照血浆的动物相比，血小板计数和巨型血小板数量分别升高了1.8倍和3.4倍。在经过类似处理的脾切除动物中未出现这种升高；当从脾切除动物获得慢性失血血浆时，完整受体动物的血小板计数或巨型血小板数量也未升高。结论是，慢性失血引起的血小板增多需要完整脾脏的存在。数据表明存在一种释放因子，其产生和表达都需要脾脏。
