Freedman M L, Karpatkin S
Br J Haematol. 1975 Oct;31(2):255-62. doi: 10.1111/j.1365-2141.1975.tb00855.x.
Rabbits were either splenectomized or subjected to splenic blockade with phenylhydrazine in order to determine the splenic platelet and megathrombocyte (large-platelet) pools. The average splenic platelet pool calculated from both methods was 35% of total platelets. The average splenic megathrombocyte pool was 54% of total megathrombocytes. Adrenaline injection into rabbits or dogs revealed a rapid increase in both platelet count and megathrombocyte number which peaked at 2-6 min and returned toward normal in 5-10 min. The platelet volume distribution curve was shifted to the right, indicating the release of large platelets (megathrombocytes) into the circulation. The peak rise in megathrombocyte number was significantly greater than the peak rise in platelet count. Rabbits subjected to splenic massage shifted their platelet volume distribution curve to the right in the absence of a rise in platelet count. It is concluded that the spleen preferentially sequesters megathrombocytes.
为了确定脾脏中的血小板和巨血小板（大血小板）池，对兔子进行了脾切除术或用苯肼进行脾脏阻断。通过这两种方法计算出的脾脏平均血小板池占总血小板的35%。脾脏平均巨血小板池占总巨血小板的54%。给兔子或狗注射肾上腺素后，血小板计数和巨血小板数量迅速增加，在2 - 6分钟时达到峰值，5 - 10分钟后恢复正常。血小板体积分布曲线向右移动，表明有大血小板（巨血小板）释放到循环中。巨血小板数量的峰值上升明显大于血小板计数的峰值上升。接受脾脏按摩的兔子在血小板计数没有升高的情况下，其血小板体积分布曲线向右移动。得出的结论是，脾脏优先扣留巨血小板。
