Lewis J R, Parker J O, Burggraf G W
Am J Cardiol. 1978 Sep;42(3):383-7. doi: 10.1016/0002-9149(78)90932-3.
To evaluate the relation between mitral valve motion and left ventricular end-diastolic pressure, the PR-AC interval, an index derived from the electrocardiogram and mitral echogram, and the left ventricular endodiastolic pressure were determined simultaneously in 22 patients undergoing diagnostic cardiac catheterization. Intravenous infusion of dextran or administration of nitroglycerin was used to alter left ventricular end-diastolic pressure to determine if there was a predictive relation between this pressure and the PR-AC interval during acute hemodynamic manipulations. There was a weak negative correlation (r = -0.33, P less than 0.01) between this pressure and the PR-AC interval. At rest a PR-AC interval greater than 0.06 second correctly predicted a left ventricular end-diastolic pressure of less than 20 mm Hg in 15 of 16 subjects. However, in four of six subjects with a PR-AC interval of 0.06 second or less, the end-diastolic pressure was less than 20 mm Hg. After interventions that varied left ventricular end-diastolic pressure by a factor of 2, the PR-AC interval changed slightly or not at all. These data suggest that the PR-AC interval is of limited value in predicting abnormal values or serial changes in left ventricular end-diastolic pressure.
为评估二尖瓣运动与左心室舒张末期压力之间的关系，对22例接受诊断性心导管检查的患者同时测定了PR-AC间期（一种从心电图和二尖瓣超声心动图得出的指标）和左心室舒张末期压力。通过静脉输注右旋糖酐或给予硝酸甘油来改变左心室舒张末期压力，以确定在急性血流动力学操作期间该压力与PR-AC间期之间是否存在预测关系。该压力与PR-AC间期之间存在弱负相关（r = -0.33，P＜0.01）。静息时，16名受试者中有15名PR-AC间期大于0.06秒可正确预测左心室舒张末期压力小于20 mmHg。然而，在PR-AC间期为0.06秒或更短的6名受试者中，有4名舒张末期压力小于20 mmHg。在使左心室舒张末期压力变化2倍的干预措施后，PR-AC间期略有变化或根本没有变化。这些数据表明，PR-AC间期在预测左心室舒张末期压力的异常值或系列变化方面价值有限。
