Ralston G B
Biochim Biophys Acta. 1976 Nov 11;455(1):163-72. doi: 10.1016/0005-2736(76)90161-9.
The tetramer of bovine spectrin has been purified and characterized in terms of its hydrodynamic and optical properties. (1) The molecular weight, from both sedimentation equilibrium and sedimentation velocity/diffusion measurements, is close to one million. (2) The hydrodynamic properties suggest a highly expanded but basically symmetrical molecule of Stokes radius 200 A. (3) Optical rotatory dispersion measurements indicate a high degree of order in the tertiary structure of the molecule. These results are not consistent with the assumption that is often made, that the spectrin molecule is a long fibrous rod.
牛血影蛋白四聚体已通过其流体动力学和光学性质进行了纯化和表征。（1）通过沉降平衡以及沉降速度/扩散测量得到的分子量接近一百万。（2）流体动力学性质表明该分子高度伸展但基本对称，斯托克斯半径为200埃。（3）旋光色散测量表明该分子三级结构具有高度的有序性。这些结果与通常所做的假设不一致，即血影蛋白分子是一个长纤维杆状分子。
