Jirka J, Burianova B, Jirka M, Blanicky P
Biomedicine. 1976 Sep 30;25(7):246-8.
The serum concentrations of Zn-alpha 2-glycoprotein (ZnaGP) were found to be increased in renal patients with both normal and restricted function; in the latter they showed significant correlation with serum creatinine and urea levels and a decrease after haemodialysis. Renal clearance of ZnaGP studied in four subjects was found to be from 0.1 to 0.8 per cent of that of inulin, and its excretion fraction was inversely proportional to the level of inulin clearance. The significance of the association of hyper-ZnaGP-aemia with renal pathology is unknown; it is supposed to be due rather to some defect in metabolic function of the kidney (utilization or degradation) than to restricted excretion, and its decrease after haemodialysis-with dialysis membrane not permeable to ZnaGP - to be caused by other factors than by the removal of the protein from the body.
研究发现，无论是肾功能正常还是受限的肾病患者，其血清锌α2糖蛋白（ZnaGP）浓度均升高；在后者中，ZnaGP浓度与血清肌酐和尿素水平显著相关，且血液透析后有所下降。在四名受试者中进行的ZnaGP肾清除率研究发现，其清除率为菊粉清除率的0.1%至0.8%，且其排泄分数与菊粉清除率水平呈反比。高ZnaGP血症与肾脏病理之间关联的意义尚不清楚；推测这与其说是由于肾脏代谢功能（利用或降解）存在某些缺陷，而非排泄受限，且血液透析后（透析膜对ZnaGP不可渗透）其下降是由除蛋白质从体内清除之外的其他因素引起的。
