Panov A V, Konstantinov Iu M, Solov'ev V N, Vavilin V A, Liakhovich V V
Biull Eksp Biol Med. 1976 Sep;82(9):1059-61.
After 4 injections of phenobarbital (PB), 3-methylcholantrene in olive oil (MC) or olive oil alone the corresponding concentrations of acyl-CoAs in the liver (in per cent to control) were: 73, 167, 230. The liver mitochondria from rats injected with oil and MC showed inhibition of the metabolic state 3 respiratory rate after Chance, Preincubation with carnitine elimated this inhibition. In accordance with these data the blood ketone body level in the administration of PB, MC and oil were 31, 136, and 342%, respectively. The phosphate potential value declined only after the injections of olive oil when the ATP concentration in the liver was markedly diminished. The AMP concentration doubled in the liver of rats after the PB and oil injection. Comparison of the data on the induction of microsomal monoxigenases by PB and MC permitted to draw a conclusion that there was a different metabolic fate of acyl-CoAs in these two cases.
分别注射4次苯巴比妥（PB）、溶于橄榄油的3-甲基胆蒽（MC）或仅注射橄榄油后，肝脏中相应的酰基辅酶A浓度（相对于对照组的百分比）分别为：73、167、230。注射油和MC的大鼠的肝脏线粒体在Chance之后显示出代谢状态3呼吸速率受到抑制，用肉碱预孵育可消除这种抑制。根据这些数据，注射PB、MC和油时血液中酮体水平分别为31%、136%和342%。仅在注射橄榄油后，当肝脏中的ATP浓度显著降低时，磷酸势值才下降。注射PB和油后，大鼠肝脏中的AMP浓度增加了一倍。比较PB和MC对微粒体单加氧酶的诱导数据，可以得出结论，在这两种情况下酰基辅酶A有不同的代谢命运。
