[癌前疾病及胃癌患者胃黏膜中游离谷氨酰胺浓度和谷氨酰胺酶活性]
[Concentration of free glutamine and glutaminase activity in the gastric mucosa of patients with precancerous diseases and cancer of the stomach].
作者信息
Aptekar' I S
出版信息
Biull Eksp Biol Med. 1976 Sep;82(9):1106-8.
Free glutamine content and phosphate-dependent glutaminase activity were studied in the biopsy specimens from the tissue of ulcer, polyps, carcinoma and the surrounding gastric mucosa of patients with precancerous diseases and carcinoma of the stomach. The glutamine content in carcinoma was not significantly different from that in the normal gastric mucosa. The glutamine level in the gastric mucosa remote from the tumour was considerably higher than normal. In case of polyposis of the stomach glutamine was present in the polyps and absent in the remote gastric mucosa. A marked glutaminase activity was revealed in the carcinoma of the stomach, but its level did not differ from the normal or in the case of precancerous diseases.
对胃癌及癌前疾病患者溃疡、息肉、癌组织及周围胃黏膜组织活检标本中的游离谷氨酰胺含量和磷酸依赖性谷氨酰胺酶活性进行了研究。癌组织中的谷氨酰胺含量与正常胃黏膜中的无显著差异。远离肿瘤的胃黏膜中谷氨酰胺水平明显高于正常水平。胃息肉病时，息肉中有谷氨酰胺，而远离息肉的胃黏膜中则没有。在胃癌组织中发现了显著的谷氨酰胺酶活性，但其水平与正常组织或癌前疾病时并无差异。
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