大鼠海马体中的谷氨酸拮抗剂。
Glutamate antagonists in rat hippocampus.
作者信息
Segal M
出版信息
Br J Pharmacol. 1976 Nov;58(3):341-5. doi: 10.1111/j.1476-5381.1976.tb07710.x.
Abstract
1 Hippocampal cellular responses to acidic amino acids and some of their antagonists were measured in the rat anaesthetized with urethane. The effects of these antagonists of the field responses of the rat hippocampus to afferent stimulation were measured in acute as well as chronically prepared rats. 2. Hippocampal pyramidal cells were excited by microiontophoretic application of glutamate and aspartate. These responses were antagonized by glutamic acid diethyl ester (GDEE), glutamic acid dimethyl ester (GDME) and by proline. Partial specificity could be seen as excitatory responses to acetylcholine were less susceptible to the antagonists. 3 field responses of the hippocampus to commissural stimulation were reduced significantly in both an acutely prepared or the conscious rat following parenteral administration of GDEE and GDME but not proline. Responses to perforant path stimulation were not affected by these drugs. 4 It is suggested that an acidic amino acid may serve as a neurotransmitter in the commissural path to-area CA1 of the dorsal hippocampus.
摘要
- 在用乌拉坦麻醉的大鼠中测量了海马体对酸性氨基酸及其一些拮抗剂的细胞反应。在急性制备以及长期制备的大鼠中测量了这些拮抗剂对大鼠海马体对传入刺激的场反应的影响。2. 通过微量离子电泳施加谷氨酸和天冬氨酸可使海马体锥体细胞兴奋。这些反应受到二乙基亚氨基谷氨酸酯（GDEE）、二甲基亚氨基谷氨酸酯（GDME）和脯氨酸的拮抗。可以看出部分特异性，因为对乙酰胆碱的兴奋反应对拮抗剂不太敏感。3. 在急性制备的大鼠或清醒大鼠中，经肠胃外给予GDEE和GDME后，海马体对连合刺激的场反应显著降低，但脯氨酸不会。对穿通通路刺激的反应不受这些药物影响。4. 有人提出，酸性氨基酸可能在背侧海马体到CA1区的连合通路中作为神经递质起作用。
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