Bukowski R M, Barna B, Deodhar S D, Hewlett J S
Cancer. 1976 Nov;38(5):1962-7. doi: 10.1002/1097-0142(197611)38:5<1962::aid-cncr2820380517>3.0.co;2-3.
Mononuclear cell-mediated tumor cell destruction was studied in 114 patients with malignant melanoma, renal cell carcinoma, or sarcomas, and in 122 non-tumor-bearing control subjects, with the use of the microcytoxicity assay. Cytotoxic reactions were found in all patients and control groups against melanoma, renal carcinoma, sarcoma, and fibroblast-derived cell cultures; mean levels of cytotoxicity against allogeneic combinations of tumor cells and fibroblasts were similar in tumor-bearing and control patients. These results support the concept that the reactions found represent nonspecific cytotoxicity.
采用微量细胞毒性试验，对114例恶性黑色素瘤、肾细胞癌或肉瘤患者以及122例无肿瘤的对照受试者进行了单核细胞介导的肿瘤细胞破坏研究。在所有患者组和对照组中均发现了针对黑色素瘤、肾癌、肉瘤和成纤维细胞来源细胞培养物的细胞毒性反应；荷瘤患者和对照患者中，针对肿瘤细胞与成纤维细胞的同种异体组合的细胞毒性平均水平相似。这些结果支持了所发现的反应代表非特异性细胞毒性这一概念。
