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[心脏传导的超常期。在狗身上的实验研究]

[The supernormal phase of cardiac conduction. An experimental study in the dog].

作者信息

Cabasson J, Morena H, Guimond C, Deceuninck P, Gagné P, Cinca J, Rocca J, Sassine A, Masse C, Puech P

出版信息

Arch Mal Coeur Vaiss. 1978 Jun;71(6):691-700.

PMID:99112
Abstract

The existence of a cardiac phase of supernormal excitability is not fully proved at the cellular level. As far as the whole heart is concerned, the phenomenon of supernormal conduction is still under discussion. Intracardiac conduction has been studied both in the right atrium (13 dogs) and in the right ventricle (14 dogs) by programmed stimulation (extrastimulus technique), while monophasic action potential (MAP) was recorded. The phenomenon of supernormal conduction was noted in 67.7% of cases, starting at 59.0% and ending at 78.0% of the basic cycle, hence occuring shortly after phase 3 of the MAP. In the ventricle, a phase of supernormal conduction was present in 52.4% of cases, starting at 66.1% and ending at 77.9% of the basic cycle. After ajmaline, the supernormal conduction was moved towards the end of the cycle. The mechanism of supernormal conduction, and its implications in the study of arrhythmias are discussed.

摘要

超常兴奋性的心相在细胞水平上尚未得到充分证实。就整个心脏而言,超常传导现象仍在讨论中。通过程控刺激(额外刺激技术)在右心房(13只犬)和右心室(14只犬)研究了心内传导,同时记录单相动作电位(MAP)。在67.7%的病例中观察到超常传导现象,起始于基本周期的59.0%,终止于78.0%,因此在MAP的第3相后不久出现。在心室中,52.4%的病例存在超常传导期,起始于基本周期的66.1%,终止于77.9%。使用阿义马林后,超常传导移向周期末期。文中讨论了超常传导的机制及其在心律失常研究中的意义。

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