Samson W K, Bode A M, Murphy T C, Resch Z T
Department of Physiology, University of North Dakota School of Medicine, 501 N. Columbia Road, Grand Forks, ND 58202, USA.
Brain Res. 1999 Feb 6;818(1):164-7. doi: 10.1016/s0006-8993(98)01268-2.
Adrenomedullin (AM), a potent hypotensive peptide, is produced in numerous tissues including adrenal gland, kidney, brain and pituitary gland, where it acts to modify sodium homeostasis. Central AM administration dose-dependently inhibits sodium appetite. AM antisense oligonucleotide treatment significantly lowered peptide content in the hypothalamic paraventricular (PVN) nucleus and exaggerated the consumption of sodium. These results support a physiologic role for adrenomedullin gene products in the central regulation of sodium homeostasis.
肾上腺髓质素（AM）是一种强效降压肽，在包括肾上腺、肾脏、脑和垂体在内的多种组织中产生，在这些组织中它发挥作用以调节钠稳态。中枢给予AM可剂量依赖性地抑制钠食欲。AM反义寡核苷酸处理显著降低了下丘脑室旁核（PVN）中的肽含量，并加剧了钠的消耗。这些结果支持肾上腺髓质素基因产物在钠稳态中枢调节中的生理作用。
