沙门氏菌脂多糖核心中所有可及的表位都与分支残基相关。
All accessible epitopes in the Salmonella lipopolysaccharide core are associated with branch residues.
作者信息
Nnalue N A
机构信息
Department of Medical Microbiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
出版信息
Infect Immun. 1999 Feb;67(2):998-1003. doi: 10.1128/IAI.67.2.998-1003.1999.
Abstract
Antisera generated against each of the nine known chemotypes of Salmonella lipopolysaccharide (LPS) core were characterized in order to delineate cross-reactive epitopes and define the bases for their accessibility. Strongly cross-reactive epitopes were associated with three chemotypes: Ra and Rb4, which recognized alpha-GlcNAc-1-->2-alpha-Glc, and Rd1, which recognized L-alpha-D-heptose-1-->7-L-alpha-D-heptose. Both these disaccharides and the more weakly cross-reactive alpha-Gal-1-->6-alpha-Glc terminal in Rb3 LPS represent branch points along the core oligosaccharide. Therefore, branch points in endotoxin core oligosaccharides may generally be cross-reactive.
摘要
为了描绘交叉反应性表位并确定其可及性的基础，对针对沙门氏菌脂多糖（LPS）核心的九种已知化学型各自产生的抗血清进行了表征。强交叉反应性表位与三种化学型相关：Ra和Rb4，它们识别α-GlcNAc-1→2-α-Glc，以及Rd1，它识别L-α-D-庚糖-1→7-L-α-D-庚糖。这两种二糖以及Rb3 LPS中交叉反应性较弱的α-Gal-1→6-α-Glc末端均代表核心寡糖上的分支点。因此，内毒素核心寡糖中的分支点通常可能具有交叉反应性。
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本文引用的文献
1
Galactose-sensitive mutants of Salmonella. II. Bacteriolysis induced by galactose.沙门氏菌的半乳糖敏感突变体。II. 半乳糖诱导的细菌溶解
Biochim Biophys Acta. 1961 Apr 15;48:470-83. doi: 10.1016/0006-3002(61)90045-2.
2
alpha-GlcNAc-1-->2-alpha-glc, the Salmonella homologue of a conserved lipopolysaccharide motif in the Enterobacteriaceae, elicits broadly cross-reactive antibodies.α-1,2-连接的N-乙酰葡糖胺，即肠杆菌科中保守脂多糖基序的沙门氏菌同源物，可引发广泛交叉反应的抗体。
Infect Immun. 1998 Sep;66(9):4389-96. doi: 10.1128/IAI.66.9.4389-4396.1998.
3
Relationship between preoperative endotoxin immune status, gut perfusion, and outcome from cardiac valve replacement surgery.心脏瓣膜置换手术术前内毒素免疫状态、肠道灌注与手术结果之间的关系。
Chest. 1997 Nov 5;112(5):1189-96. doi: 10.1378/chest.112.5.1189.
4
5
The beta-configuration of the rhamnosidic linkage in Salmonella serogroups C2 and C3 lipopolysaccharide is important for the immunochemistry of the O-antigen 8.
Mol Immunol. 1993 Jul;30(10):887-93. doi: 10.1016/0161-5890(93)90012-z.
6
7
A controlled field trial of live Salmonella typhi strain Ty 21a oral vaccine against typhoid: three-year results.伤寒沙门氏菌Ty 21a口服活疫苗预防伤寒的对照现场试验：三年结果
J Infect Dis. 1982 Mar;145(3):292-5. doi: 10.1093/infdis/145.3.292.
8
Escherichia coli antibodies in opsonisation and protection against infection.大肠杆菌抗体在调理作用及抗感染中的作用。
J Med Microbiol. 1981 Nov;14(4):381-9. doi: 10.1099/00222615-14-4-381.
9
Structural studies on the hexose region of the core in lipopolysaccharides from Enterobacteriaceae.肠杆菌科脂多糖核心己糖区域的结构研究。
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10
Immunization against nosocomial infection.医院感染的免疫接种。
Am J Med. 1981 Feb;70(2):463-6. doi: 10.1016/0002-9343(81)90789-0.
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