Pankov Y A
Institute of Experimental Endocrinology, Endocrine Research Center, Russian Academy of Medical Sciences, Moscow, 115478, Russia.
Biochemistry (Mosc). 1998 Dec;63(12):1361-73.
This review considers results of studies on six hormones-- leptin, adrenomedullin, parathyroid hormone-related protein, vascular endothelium growth factor, fibroblast growth factor 2, and prolactin. Genes of these hormones are markedly expressed in various tissues which can synthesize and release the corresponding hormones into the intercellular space and blood. The structure of hormone receptor genes and their expression in various tissues which are target organs of the hormones are discussed. All organs, tissues, and cells of the body are concluded to be endocrine and releasing their specific hormones into blood. Hormones regulate vital processes, provide communications between organs and tissues, and integrate them into a united entity. All hormones are multifunctional compounds of wide spectrum of biological activities. The regulation of gene expression via various mechanisms is a common property of all hormones. Many tissue-specific hormones are yet to be discovered.
本综述探讨了六项关于激素的研究结果，这六项激素分别是：瘦素、肾上腺髓质素、甲状旁腺激素相关蛋白、血管内皮生长因子、成纤维细胞生长因子2和催乳素。这些激素的基因在各种组织中均有显著表达，这些组织能够合成相应激素并将其释放到细胞间液和血液中。文中还讨论了激素受体基因的结构及其在作为激素靶器官的各种组织中的表达情况。得出的结论是，机体的所有器官、组织和细胞均具有内分泌功能，并将其特定激素释放到血液中。激素调节生命过程，实现器官与组织间的通讯，并将它们整合为一个统一的整体。所有激素都是具有广泛生物活性的多功能化合物。通过各种机制调节基因表达是所有激素的共同特性。许多组织特异性激素仍有待发现。
