Nenoff P, Kellermann S, Schober R, Nenning H, Kubel M, Winkler J, Haustein U F
Department of Dermatology, University of Leipzig, Germany.
Mycoses. 1998 Nov;41(9-10):365-72. doi: 10.1111/j.1439-0507.1998.tb00355.x.
We report on a man suffering from chronic myelogenous leukaemia treated by allogeneic bone marrow transplantation who, in the late post-transplantation phase, developed a hyperacute fatal invasive rhinocerebral zygomycosis. The origin of the ascending infection was the sinus sphenoidalis from which fungal hyphae spread to the central nervous system via the skull and the dura mater. The first symptoms of this severe infection were cerebral convulsions and a bilateral total amaurosis. The isolation of the pathogen from post mortem tissue was not successful. The present case is compared with previous reports of zygomycoses after bone marrow transplantation.
我们报告了一名接受异基因骨髓移植治疗的慢性粒细胞白血病男性患者，该患者在移植后期发生了超急性致命性侵袭性鼻脑接合菌病。上行感染的源头是蝶窦，真菌菌丝从蝶窦经颅骨和硬脑膜扩散至中枢神经系统。这种严重感染的最初症状是脑部抽搐和双侧完全性黑矇。从尸检组织中未能成功分离出病原体。将本病例与先前关于骨髓移植后接合菌病的报告进行了比较。
