Reich H, Opitz K, Bertram H P, Fegeler K
Dtsch Med Wochenschr. 1976 Nov 19;101(47):1724-6. doi: 10.1055/s-0028-1104329.
A 24-year-old patient treated with hydroxychinoline preparations without cure for acrodermatitis enteropathica since he was nine years old was given zinc oxide orally, at first 50 mg three times, later twice daily. Zinc concentrations in blood plasma, whole blood and sputum were serially determined. At the start of treatment they were significantly below that in four healthy controls. One week after starting zinc therapy the blood level had returned to normal and with it the changes in skin, hair and nails had regressed, as had the emotional disturbances.
一名24岁患者自9岁起就使用羟基氯喹啉制剂治疗肠病性肢端皮炎,但未治愈。该患者开始口服氧化锌,起初每日3次,每次50毫克,之后改为每日2次。连续测定血浆、全血和痰液中的锌浓度。治疗开始时,这些锌浓度显著低于4名健康对照者。开始锌治疗1周后,血液中的锌水平恢复正常,同时皮肤、头发和指甲的变化以及情绪障碍也都有所改善。