Prostaglandin-forming cyclooxygenase in renal medulla of spontaneously hypertensive rats during development.

Increased activity of prostaglandin synthetase in spontaneously hypertensive rats (SHR) during development has previously been reported. The investigations reported herein utilized an immunofluorescent technique to qualitatively assess the activity of the first enzyme in the PGE2 biosynthetic pathway, the prostaglandin-forming cyclooxygenase (PG-C), in SHR kidneys during development. PG-C antigenicity increased from 4 to 15 weeks in both SHRs and Wistar Kyoto normotensive rats. However, in agreement with our previous in vitro data no difference in PG-C was observed between strains at any age.