以单异构体七（2,3 - 二甲基 - 6 - 硫酸根）-β-环糊精为拆分剂、甲醇为背景电解质溶剂，采用毛细管电泳法分离弱碱对映体。
Capillary electrophoretic separation of weak base enantiomers using the single-isomer heptakis-(2,3-dimethyl-6-sulfato)-beta-cyclodextrin as resolving agent and methanol as background electrolyte solvent.
作者信息
Cai H, Vigh G
机构信息
Department of Chemistry, Texas A&M University, College Station 77842-3012, USA.
出版信息
J Pharm Biomed Anal. 1998 Dec;18(4-5):615-21. doi: 10.1016/s0731-7085(98)00277-5.
The sodium salt of the single-isomer, heptakis-(2,3-dimethyl-6-sulfato)-beta-cyclodextrin (HDMS-betaCD) was used as resolving agent in the capillary electrophoretic (CE) separation of weak base enantiomers in pure methanol background electrolytes (BEs). According to the requirements of the charged resolving agent migration model of CE enantiomer separations (CHARM model), a high buffer-capacity, low pH methanolic BE was created from 25 mM phosphoric acid and 12.5 mM NaOH. In this BE, the solubility of HDMS-betaCD was as high as 50 mM, permitting the realization of very high separation selectivities and short separation times for the fully protonated weak base enantiomers.
单异构体七（2,3 - 二甲基 - 6 - 硫酸根）-β-环糊精（HDMS-βCD）的钠盐被用作毛细管电泳（CE）中在纯甲醇背景电解质（BEs）里分离弱碱对映体的拆分剂。根据CE对映体分离的带电拆分剂迁移模型（CHARM模型）的要求，用25 mM磷酸和12.5 mM氢氧化钠配制了一种高缓冲容量、低pH值的甲醇BE。在这种BE中，HDMS-βCD的溶解度高达50 mM，使得对于完全质子化的弱碱对映体能够实现非常高的分离选择性和较短的分离时间。
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