Tähtinen T M, Vanhala M J, Oikarinen J A, Keinänen-Kiukaanniemi S M
Oulu Deaconess Institute, Sepänkatu, Finland.
J Cardiovasc Risk. 1998 Oct-Dec;5(5-6):319-23.
Obesity, central obesity, hypertension, dyslipidemia and hyperinsulinemia tend to cluster in the same individuals as a metabolic syndrome; smoking has an adverse effect on insulin resistance. The aim of our study was to examine the occurrence of clusters of insulin-resistance-associated abnormalities and the effect of smoking on this clustering in young men.
In 1995 we invited all the 1268 servicemen attending military service in the Ostrobothnian Brigade, Finland, for screening of the metabolic syndrome. The first phase consisted of an interview concerning smoking and measurements of blood pressure, weight, height, waist and hip circumferences. If diastolic pressure was > 85 mmHg, body mass index > 27 or waist-to-hip ratio > 0.98, these participants were invited to blood samples for the measurements of fasting serum lipids, plasma glucose and insulin. These results were obtained from 144 screening-positive men (120%) and from their 79(7%) randomly selected controls.
The metabolic syndrome, defined as plasma insulin > or = 13.0 mU/l and serum triglycerides > or = 1.70 mmol/l and/or total cholesterol/high-density lipoprotein cholesterol > 5.0, was present in 10% (n = 1 4) of the screening-positive participants. None of the randomly selected controls had the metabolic syndrome. The metabolic syndrome was present in 12% (n = 11) of 93 smokers and in 2% (n = 3) of 1 28 non-smokers (P= 0.004).
We conclude that clusters of metabolic abnormalities associated with insulin resistance are already present in young men, and that the prevalence of these clusters in smokers is sixfold compared with non-smokers.
肥胖、中心性肥胖、高血压、血脂异常和高胰岛素血症往往在同一个体中聚集形成代谢综合征；吸烟对胰岛素抵抗有不良影响。我们研究的目的是调查胰岛素抵抗相关异常聚集的发生情况以及吸烟对年轻男性中这种聚集的影响。
1995年，我们邀请了芬兰奥鲁军团所有1268名服兵役的军人进行代谢综合征筛查。第一阶段包括询问吸烟情况以及测量血压、体重、身高、腰围和臀围。如果舒张压>85mmHg、体重指数>27或腰臀比>0.98，这些参与者将被邀请采集血样以测量空腹血脂、血糖和胰岛素。这些结果来自144名筛查阳性男性（120%）及其79名（7%）随机选择的对照。
代谢综合征定义为血浆胰岛素≥13.0mU/l且血清甘油三酯≥1.70mmol/l和/或总胆固醇/高密度脂蛋白胆固醇>5.0，在10%（n=14）的筛查阳性参与者中存在。随机选择的对照中无人患有代谢综合征。代谢综合征在93名吸烟者中的发生率为12%（n=11），在128名非吸烟者中的发生率为2%（n=3）（P=0.004）。
我们得出结论，与胰岛素抵抗相关的代谢异常聚集在年轻男性中已经存在，并且这些聚集在吸烟者中的患病率是非吸烟者的六倍。
