城市人群中的空腹血糖与心血管危险因素

Fasting glucose and cardiovascular risk factors in an urban population.

作者信息

Gupta R, Sarna M, Thanvi Jyoti, Sharma Vibha, Gupta V P

机构信息

Monilek Hospital and Research Centre, Jaipur, India.

出版信息

J Assoc Physicians India. 2007 Oct;55:705-9.

PMID:18173023

Abstract

OBJECTIVE

To test the hypothesis that blood glucose levels in the range of normoglycemia are associated with increased cardiovascular risk we performed an epidemiological study in an urban population.

METHODS

Randomly selected adults > or = 20 years were studied using stratified sampling. Target sample was 1800 (men 960, women 840) of which 1123 subjects participated. Blood samples were available in 1091 subjects (60.6%, men 532, women 559). Measurement of anthropometric variables, blood pressure, fasting blood glucose and lipids was performed. Cardiovascular risk factors were determined using US Adult Treatment Panel-3 guidelines. Pearson's correlation coefficients (r) of fasting glucose with various risk factors were determined. Fasting glucose levels were classified into various groups as < 75 mg/dl, 75-89 mg/dl, 90-109 mg/dl, 110-125 mg/dl and > 126 mg/dl or known diabetes. Prevalence of cardiovascular risk factors was determined in each group.

RESULTS

There was a significant positive correlation of fasting glucose in men and women with body mass index (r = 0.20, 0.12), waist-hip ratio (0.17, 0.09), systolic blood pressure (0.07, 0.22), total cholesterol (0.21, 0.15) and triglycerides (0.21, 0.25). Prevalence (%) of cardiovascular risk factors in men and women was smoking/tobacco use in 37.6 and 11.6, hypertension in 37.0 and 37.6, overweight and obesity in 37.8 and 50.3, truncal obesity in 57.3 and 68.0, high cholesterol > or = 200 mg/dl in 37.4 and 45.8, high triglycerides > or = 150 mg/dl in 32.3 and 28.6 and metabolic syndrome in 22.9 and 31.6 percent. In various groups of fasting glucose there was an increasing trend in prevalence of overweight/obesity, hypertension, hypercholesterolaemia, hypertriglyceridaemia, and metabolic syndrome (Mantel-Haenzel X2 for trend, p < 0.05) and fasting glucose < 75 mg/dl was associated with the lowest prevalence of these risk factors.

CONCLUSIONS

There is a continuous relationship of fasting glucose levels with many cardiovascular risk factors and level < 75 mg/dl is associated with the lowest prevalence.

摘要

目的

为验证正常血糖范围内的血糖水平与心血管疾病风险增加相关这一假设，我们在城市人群中开展了一项流行病学研究。

方法

采用分层抽样法对随机选取的年龄≥20岁的成年人进行研究。目标样本为1800人（男性960人，女性840人），其中1123名受试者参与研究。1091名受试者（60.6%，男性532人，女性559人）有血样。测量人体测量学变量、血压、空腹血糖和血脂。使用美国成人治疗小组第三次指南确定心血管危险因素。确定空腹血糖与各种危险因素的Pearson相关系数（r）。空腹血糖水平分为<75mg/dl、75 - 89mg/dl、90 - 109mg/dl、110 - 125mg/dl和>126mg/dl或已知糖尿病等不同组。确定每组中心血管危险因素的患病率。

结果

男性和女性的空腹血糖与体重指数（r = 0.20，0.12）、腰臀比（0.17，0.09）、收缩压（0.07，0.22）、总胆固醇（0.21，0.15）和甘油三酯（0.21，0.25）呈显著正相关。男性和女性心血管危险因素的患病率（%）分别为：吸烟/使用烟草37.6%和11.6%、高血压37.0%和37.6%、超重和肥胖37.8%和50.3%、腹型肥胖57.3%和68.0%、高胆固醇≥200mg/dl 37.4%和45.8%、高甘油三酯≥150mg/dl 32.3%和28.6%、代谢综合征22.9%和31.6%。在空腹血糖的不同组中，超重/肥胖、高血压、高胆固醇血症、高甘油三酯血症和代谢综合征的患病率呈上升趋势（趋势性Mantel - Haenzel X2检验，p < 0.05），空腹血糖<75mg/dl与这些危险因素的最低患病率相关。