肝素的抗凝活性：抗凝血酶结合位点的分离 - Suppr

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超能文献

Anticoagulant activity of heparin: isolation of antithrombin-binding sites.

作者信息

Hopwood J, Höök M, Linker A, Lindahl U

出版信息

FEBS Lett. 1976 Oct 15;69(1):51-4. doi: 10.1016/0014-5793(76)80651-5.

DOI:10.1016/0014-5793(76)80651-5

PMID:992045

Abstract

摘要

相似文献

Anticoagulant activity of heparin: isolation of antithrombin-binding sites.肝素的抗凝活性：抗凝血酶结合位点的分离

FEBS Lett. 1976 Oct 15;69(1):51-4. doi: 10.1016/0014-5793(76)80651-5.

Anticoagulant activity of heparin: separation of high-activity and low-activity heparin species by affinity chromatography on immobilized antithrombin.肝素的抗凝活性：通过固定化抗凝血酶亲和色谱法分离高活性和低活性肝素种类

FEBS Lett. 1976 Jul 1;66(1):90-3. doi: 10.1016/0014-5793(76)80592-3.

Structure and antithrombin-binding properties of heparin isolated from the clams Anomalocardia brasiliana and Tivela mactroides.从巴西心蛤（Anomalocardia brasiliana）和大獭蛤（Tivela mactroides）中分离出的肝素的结构及抗凝血酶结合特性

J Biol Chem. 1987 Aug 25;262(24):11413-21.

Binding to antithrombin of heparin fractions with different molecular weights.不同分子量肝素组分与抗凝血酶的结合

Biochem J. 1981 Feb 1;193(2):427-33. doi: 10.1042/bj1930427.

High-activity heparin: chain length, affinity for antithrombin, and anticoagulant activity.高活性肝素：链长、对抗凝血酶的亲和力及抗凝活性。

Arch Biochem Biophys. 1982 Apr 15;215(1):163-70. doi: 10.1016/0003-9861(82)90291-0.

Heparin with two binding sites for antithrombin or platelet factor 4.具有两个抗凝血酶或血小板第4因子结合位点的肝素。

J Biol Chem. 1982 Jan 10;257(1):400-6.

The uronic acid composition of anticoagulantly active and inactive heparin.具有抗凝活性和无抗凝活性的肝素的糖醛酸组成。

Arch Biochem Biophys. 1985 Nov 1;242(2):574-8. doi: 10.1016/0003-9861(85)90245-0.

Characterization of a new potent heparin. 5th Communication: Further characterization by affinity chromatography on antithrombin-sepharose and its comparison with a commercially available heparin.一种新型高效肝素的特性研究。第五篇通讯：通过抗凝血酶-琼脂糖亲和层析进一步表征及其与市售肝素的比较。

Arzneimittelforschung. 1980;30(10):1621-3.

Interaction of heparin with proteins. Demonstration of different binding sites for antithrombin and lipoprotein lipase.肝素与蛋白质的相互作用。抗凝血酶和脂蛋白脂肪酶不同结合位点的证明。

FEBS Lett. 1977 Jul 1;79(1):59-63. doi: 10.1016/0014-5793(77)80350-5.

Highly active heparin species with multiple binding sites for antithrombin.具有多个抗凝血酶结合位点的高活性肝素种类。

Biochem Biophys Res Commun. 1979 Feb 28;86(4):1319-24. doi: 10.1016/0006-291x(79)90260-2.

引用本文的文献

Identification of Protein Recognition Elements within Heparin Chains Using Enzymatic Foot-Printing in Solution and Online SEC/MS.使用溶液内酶切足迹法和在线 SEC/MS 鉴定肝素链中的蛋白识别元件。

Anal Chem. 2020 Jun 2;92(11):7565-7573. doi: 10.1021/acs.analchem.0c00115. Epub 2020 May 13.

Elucidating the specificity of non-heparin-based conformational activators of antithrombin for factor Xa inhibition.阐明抗凝血酶的非肝素类构象激活剂对Xa因子抑制作用的特异性。

J Nat Sci Biol Med. 2014 Jan;5(1):36-42. doi: 10.4103/0976-9668.127282.

Heparan sulfate 3-O-sulfation: a rare modification in search of a function.硫酸乙酰肝素3-O-硫酸化：寻找功能的罕见修饰。

Matrix Biol. 2014 Apr;35:60-72. doi: 10.1016/j.matbio.2013.12.001. Epub 2013 Dec 19.

RGD-xyloside conjugates prime glycosaminoglycans.RGD-木糖苷缀合物使糖胺聚糖预激活。

Glycoconj J. 2010 Aug;27(6):625-33. doi: 10.1007/s10719-010-9306-1. Epub 2010 Aug 18.

The structure of heparin oligosaccharide fragments with high anti-(factor Xa) activity containing the minimal antithrombin III-binding sequence. Chemical and 13C nuclear-magnetic-resonance studies.具有高抗（因子Xa）活性且包含最小抗凝血酶III结合序列的肝素寡糖片段的结构。化学和13C核磁共振研究。

Biochem J. 1981 Sep 1;197(3):599-609. doi: 10.1042/bj1970599.

The molecular-weight dependence of the rate-enhancing effect of heparin on the inhibition of thrombin, factor Xa, factor IXa, factor XIa, factor XIIa and kallikrein by antithrombin.抗凝血酶对凝血酶、因子Xa、因子IXa、因子XIa、因子XIIa和激肽释放酶抑制作用中，肝素促速率效应的分子量依赖性。

Biochem J. 1981 Feb 1;193(2):395-400. doi: 10.1042/bj1930395.

Mechanism of the anticoagulant action of heparin.肝素抗凝作用的机制。

Mol Cell Biochem. 1982 Oct 29;48(3):161-82. doi: 10.1007/BF00421226.

Increased sulphation improves the anticoagulant activities of heparan sulphate and dermatan sulphate.硫酸化增强可提高硫酸乙酰肝素和硫酸皮肤素的抗凝活性。

Biochem J. 1987 Dec 15;248(3):889-96. doi: 10.1042/bj2480889.

Endothelial binding sites for heparin. Specificity and role in heparin neutralization.肝素的内皮结合位点。特异性及在肝素中和中的作用。

Biochem J. 1986 Sep 15;238(3):847-54. doi: 10.1042/bj2380847.

Fractionation of heparin by chromatography on a tissue plasminogen activator-Sepharose column.通过在组织型纤溶酶原激活剂-琼脂糖柱上进行色谱法对肝素进行分级分离。

Proc Natl Acad Sci U S A. 1990 Mar;87(5):1865-9. doi: 10.1073/pnas.87.5.1865.

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