Henwood S M, Weeks C E, Lardy H
Covance Laboratories Inc., Madison, Wisconsin.
Biochem Biophys Res Commun. 1999 Jan 8;254(1):124-6. doi: 10.1006/bbrc.1998.9908.
To test the effects of 7-oxo-dehydroepiandrosterone-3 acetate (hereafter 7-ODA) in Rhesus macaques the steroid was administered by oral gavage to two male and two female monkeys. Dose levels of 250, 500, and 1,000 mg/kg body weight (BW)/day were administered on days 1, 3, and 5 respectively, and 1,000 mg/kg on days 7 through 11. Each group received the dose in a volume of 10 ml/kg BW. All animals survived to the scheduled sacrifice on day 12. No adverse clinical effects of 7-ODA were observed at the 250 or 500 mg/kg doses. Females vomited on non-treatment days and all animals vomited on some days after being given the 1000 mg/kg dose. Excessive salivation was observed before or immediately after dosing on days 9 through 11. Appearance, behavior and body weights were not altered by the treatments. Visual examination of all body cavities, and macroscopic and microscopic examination of 42 different organs and tissues found no lesions or abnormalities.
为了测试3-醋酸7-氧代脱氢表雄酮（以下简称7-ODA）对恒河猴的影响，通过口服灌胃的方式给两只雄性和两只雌性猴子施用了这种类固醇。分别在第1、3和5天给予250、500和1000毫克/千克体重（BW）/天的剂量水平，在第7至11天给予1000毫克/千克的剂量。每组以10毫升/千克体重的体积接受剂量。所有动物均存活至预定的第12天处死。在250或500毫克/千克剂量下未观察到7-ODA的不良临床影响。雌性在非治疗日呕吐，所有动物在给予1000毫克/千克剂量后的某些日子里呕吐。在第9至11天给药前或给药后立即观察到唾液分泌过多。治疗对外观、行为和体重没有影响。对所有体腔进行视觉检查，对42个不同器官和组织进行宏观和微观检查，未发现病变或异常。
