Department of Obstetrics and Gynecology, University of Bern, Bern, Switzerland.
Medical Library, University Library Bern, University of Bern, Bern, Switzerland.
Arch Gynecol Obstet. 2023 Sep;308(3):777-785. doi: 10.1007/s00404-022-06884-8. Epub 2022 Dec 25.
7-Keto-DHEA has been commercially advertised as a dietary supplement to support weight loss. The objective of the present systematic review it to summarize the evidence supporting the use of 7-keto-DHEA in overweight and obese population. The systematic search was conducted in Medline, Embase, Cochrane Library, CINAHL, Web of Science, Scopus, ICTRP, and ClinicalTrials.gov. Additionally, reference lists of eligible studies were considered, and authors of relevant studies were contacted. Two authors independently screened the studies against the inclusion criteria and assessed their risk of bias. In total, 4 out of 686 studies were included in the review. They all held a low risk of bias. Half of them showed a significant reduction in body weight. One study found a decrease in body fat percentage and another one reported a decrease in BMI. Two studies stated an increase in resting metabolic rate. No serious adverse effects were reported. Various possible mechanisms in favor of weight loss are discussed; however, with the evidence currently available, no clear answer can be given regarding 7-keto-DHEA and weight loss. Further studies need to be conducted to clarify the efficacy and safety of this drug before it can be recommended for therapeutic use.
7-酮去氢表雄酮（7-Keto-DHEA）已被商业宣传为一种膳食补充剂，以支持减肥。本系统评价的目的是总结支持超重和肥胖人群使用 7-酮去氢表雄酮的证据。系统检索了 Medline、Embase、Cochrane 图书馆、CINAHL、Web of Science、Scopus、ICTRP 和 ClinicalTrials.gov。此外，还考虑了合格研究的参考文献列表，并联系了相关研究的作者。两位作者独立筛选了符合纳入标准的研究，并评估了其偏倚风险。总共 686 项研究中有 4 项纳入了综述。它们的偏倚风险都较低。其中一半的研究显示体重显著减轻。一项研究发现体脂百分比下降，另一项研究报告 BMI 下降。两项研究表明静息代谢率增加。没有报告严重的不良反应。讨论了支持减肥的各种可能机制；然而，根据目前的证据，对于 7-酮去氢表雄酮和减肥之间的关系，还不能给出明确的答案。在推荐其用于治疗用途之前，需要进行进一步的研究以阐明该药物的疗效和安全性。
