Angyo I A, Okpeh E S, Onah J
Department of Paediatrics and Medical Microbiology, Jos University Teaching Hospital, Nigeria.
West Afr J Med. 1998 Oct-Dec;17(4):268-72.
A retrospective study of all children admitted with the diagnosis of acquired immunodeficiency syndrome (AIDS) at Jos University Teaching Hospital (JUTH) between August 1995 and October 1996 was carried out. Forty three (1.5% out of a total of 2793 children were diagnosed with HIV infection during the study period. However, only the records of 23 out. Of the 43 positive cases were available for analysis. Of the 23 cases whose records were available, 8 presented in 1995, while the remaining 15 presented between January and October 1996. The ages of the children ranged between 1 and 15 years (Mean 3.0 +/- 4.1 Years). There were 12 males and 11 females (M:F = 1:1). Sixteen (69.6 percent) out of the 23 patients were aged between 1 month and 2 years. Sixteen (69.6%) of the 23 patients acquired the infection vertically, 2 (8.9%) acquired the infection through blood transfusion, 1 (4.3%) from sexual abuse, while in 4 (17.4%) the source of infection could not be established due to inadequate data. Majority of the children presented with weight loss, chronic diarrhoea and fever, while the common findings included wasting, oralthrush, pallor, hepatosplenomegaly and lymphadenopathy. Six (26.1 percent) out of the 23 children died, 8 (34.8 percent) were discharged against medical advice and have not been seen since, 9 (39.1%) improved and were discharged to out-patient clinic followup, but all except 2 of these have been lost to follow-up. It is concluded that AIDS is increasingly becoming a major cause of childhood morbidity and mortality in our environment. All children in our environment who present with features of malnutrition should be screened for AIDS. Campaigns aimed at preventing vertical (maternal-child) transmission, including health education of young men and women on the risk of unprotected sex must be vigorously pursued and sustained.
对1995年8月至1996年10月期间在乔斯大学教学医院(JUTH)被诊断为获得性免疫缺陷综合征(AIDS)而入院的所有儿童进行了一项回顾性研究。在研究期间,43名(占2793名儿童总数的1.5%)被诊断为感染了艾滋病毒。然而,在43例阳性病例中,仅有23例的记录可供分析。在有记录的23例病例中,8例于1995年就诊,其余15例于1996年1月至10月期间就诊。儿童年龄在1至15岁之间(平均3.0±4.1岁)。有12名男性和11名女性(男:女 = 1:1)。23例患者中有16例(69.6%)年龄在1个月至2岁之间。23例患者中有16例(69.6%)通过垂直传播感染,2例(8.9%)通过输血感染,1例(4.3%)因性虐待感染,而4例(17.4%)由于数据不足无法确定感染源。大多数儿童表现为体重减轻、慢性腹泻和发热,常见体征包括消瘦、鹅口疮、面色苍白、肝脾肿大和淋巴结病。23名儿童中有6名(26.1%)死亡,8名(34.8%)违反医嘱出院且此后未见踪影,9名(39.1%)病情好转并出院到门诊随访,但除其中2名外,其余均失访。结论是,在我们所处的环境中,艾滋病日益成为儿童发病和死亡的主要原因。在我们所处环境中,所有出现营养不良特征的儿童都应接受艾滋病筛查。必须大力开展并持续进行旨在预防垂直(母婴)传播的活动,包括对青年男女进行关于无保护性行为风险的健康教育。