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下丘脑电刺激对血小板聚集过程的影响

[Effect of electrical stimulation of the hypothalamus on the process of blood platelet aggregation].

作者信息

Ermolaev Iu A

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1976 Aug;62(8):1158-65.

PMID:992138
Abstract

Stimulation of hypothalamic ventromedial and posterior nuclei via implanted electrodes was followed by phasic changes of the blood coagulation processes and thrombocytes dynamic functions. Within the first minutes after stimulation, an increase of the blood coagulation potential, of aggregation and adhesive features of thrombocytes was observed, replaced later by reduction of thrombocytes dynamic features and by decreasing blood coagulation potential. The above changes are associated with alteration of the blood content of aggregating agents, inhibitors of aggregation, and blood coagulating factors. The hypothalamic structures are suggested to exert control over thrombocytes hemostatic functions via a humoral link.

摘要

通过植入电极刺激下丘脑腹内侧核和后核后,血液凝固过程和血小板动态功能出现阶段性变化。刺激后的最初几分钟内,观察到血液凝固潜能增加,血小板聚集和黏附特性增强,随后血小板动态特性降低,血液凝固潜能下降。上述变化与聚集剂、聚集抑制剂和凝血因子的血液含量改变有关。提示下丘脑结构通过体液联系对血小板止血功能发挥控制作用。

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